A Norfolk firm renowned across the globe for its expertise in making thermometers and barometers is set to close after 160 years.
Russell Scientific Instruments, based in Dereham, will cease to exist come the end of May.
The company was established in 1862 and has, over the years, made and repaired tens of thousands of unique products.
But owner Edward Allen learned in recent months that the business would need to leave its home in Rash's Green after the landlord opted to sell up.
And the decision has been taken not to seek new premises following a change in the law relating to Russell Scientific's main business: using the chemical element mercury in its instruments.
Despite Mr Allen's best efforts, which saw him travel three times to Brussels to fight for his staff, the European Union banned the sale of mercury thermometers to protect the environment.
"What they wanted was to ban anything to do with mercury," said the 72-year-old.
"I argued we should still at least be able to carry out repairs. There are pieces of craftsmanship which have been in museums and people's houses for 200 years.
"I even pointed to the Queen's wonderful collection of mercury barometers and said she would not be amused.
"Ultimately I won that battle, but I didn't win the war.
"By taking away the industrial side of making thermometers, our business completely shrank. Basically, we can't keep going with just the odd repair coming in."
Despite the UK now being outside the EU and no longer covered by its rules, the British government has its own laws closely regulating the use of mercury.
Russell Scientific will shut with a total of five employees on its books.
Three of them hail from Dereham and have worked there ever since leaving school at the age of 16.
Today, they are experts in their field and are still shipping items all over the world, including recently to Sri Lanka and Nigeria.
In January, one of the company's barograph's detected a pressure change caused by an undersea volcanic eruption 10,000 miles away in Tonga.
"This firm prides itself on accuracy, and that's why we always kept going," added Mr Allen.
"The repairs we do - there is nobody else left to do them. My staff are the best in the world and closing is really sad because this is a fantastic little industry."
Comments: Our rules
We want our comments to be a lively and valuable part of our community - a place where readers can debate and engage with the most important local issues. The ability to comment on our stories is a privilege, not a right, however, and that privilege may be withdrawn if it is abused or misused.
Please report any comments that break our rules.
Read the rules here