Foreign secretary Liz Truss says we must prepare for the "long haul" to ensure Russia's defeat in Ukraine as she calls for allies to supply tanks and warplanes to Kyiv.
In a major speech, the MP for South West Norfolk will argue that Vladimir Putin's invasion of Ukraine shows the need for a shake-up of the international structures which failed to prevent Russia's actions.
She will argue that Western allies need to impose even tougher economic sanctions to increase Russia's isolation, including cutting off oil and gas imports "once and for all".
"There must be nowhere for Putin to go to fund this appalling war," she will say in the speech at the Mansion House in London tonight [Wednesday, April 27].
In a call to Western allies, she will say: "We cannot be complacent - the fate of Ukraine remains in the balance.
"And let's be clear - if Putin succeeds there will be untold further misery across Europe and terrible consequences across the globe. We would never feel safe again.
"So we must be prepared for the long haul and double down on our support for Ukraine.
"Heavy weapons, tanks, aeroplanes - digging deep into our inventories, ramping up production. We need to do all of this."
Mr Putin's foreign minister, Sergei Lavrov, has warned that weapons supplied by Western countries "will be a legitimate target" and Nato has effectively "entered into a war with Russia through proxies".
Boris Johnson however has insisted the UK and other "sympathetic" countries would continue to provide Kyiv with intelligence-sharing, training and "Nato-grade" weaponry.
In an interview on Tuesday with TalkTV he indicated he would be happy to see the Ukrainians use UK-made armaments to strike targets inside Russia.
"They are being attacked from within Russia territory. They have a right to protect and defend themselves," he said.
He also dismissed reports that further defeats for Russian forces could see a frustrated Mr Putin resort to using low-yield tactical nuclear weapons against Ukraine.
"Given the massive Russian backing for what he is doing, given the apparent obliviousness of the Russian media about what is really happening in Ukraine, the paradox is that Putin has far more political space to back down, to withdraw," he said.
In the Commons, Armed Forces minister James Heappey said Britain would providing the Ukrainians with longer-range Brimstone ground attack missiles "in the next few weeks".
The UK was one of just eight Nato members to meet the alliance's goal of spending at least 2pc of gross domestic product - a measure of the size of the economy - on defence in 2021.
Ms Truss will argue that there has been a "generation of under-investment" in the West and the 2pc target should be "a floor, not a ceiling".
Ms Truss will say the Russian invasion shows "the architecture that was designed to guarantee peace and prosperity has failed Ukraine".
Russia's position as a veto-wielding member of the UN Security Council has limited that body's ability to censure the Putin regime.
Ms Truss will set out a new approach which recognises "we're seeing the return of geopolitics".
The UK and its allies must "reboot, recast and remodel our approach to deterring aggressors" and the war in Ukraine "has to be a catalyst for wider change", she will say.
"Our new approach will be based on three areas: military strength, economic security and deeper global alliances.
"I want to live in a world where free nations are assertive and in the ascendant... where freedom and democracy are strengthened through a network of economic and security partnerships... where aggressors are contained and moving toward a better path.
"This is the long-term prize: a new era of peace, security and prosperity."
An ally of the Cabinet minister said her speech is in recognition of the fact that the West has been "asleep at the wheel since the Cold War".
Ms Truss wants to see the G7 - the UK, US, Canada, Japan, France, Germany and Italy - playing a stronger role on the world stage.
She also wants to forge a stronger network of bilateral security and economic partnerships.
Shadow foreign secretary David Lammy said "Liz Truss's speech appears to be an admission of failure after more than a decade of decline".
He added: "The Conservatives wrongly de-emphasised European security in the Integrated Review, made deep cuts to the British army over many years, gave up soft power through cutting development, and hurt alliances with Europe and the United States including by risking peace in Northern Ireland."
Comments: Our rules
We want our comments to be a lively and valuable part of our community - a place where readers can debate and engage with the most important local issues. The ability to comment on our stories is a privilege, not a right, however, and that privilege may be withdrawn if it is abused or misused.
Please report any comments that break our rules.
Read the rules here